Warning! Deadly Airborne Mold Set to Spread PDF Print E-mail

A deadly, airborne new strain of fungus has emerged in Oregon. It has killed nearly one out of four known affected people so far and might also attack animals ranging from dogs to dolphins. And it is likely to spread, researchers now warn.  (MSNBC)

Fears overblown, say experts (ABC News)

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Fungal infection is not as rare as doctors in the second article would have us think. We are often contacted by formerly healthy individuals with deadly aspergillosis, from indoor mold exposures.

We find it ironic that "experts" (for defense) claim that inhaled spores can't hurt anyone w/regard to indoor molds, despite research to the contrary. VGIIc of the fungus Cryptococcus gattii is outdoors, where its spores are thinly distributed into the atmosphere - and yet, they can be deadly. The numbers are climbing for deaths and the fungus is spreading. Our comment on the second (ABC News) article, below:

As the Director of The Center for School Mold Help, I can say that the same type of naysaying has been used by physicians with regard to the effects of mold (fungi) on health for decades. Even the CDC has now changed its tune - mold (fungi) is dangerous to health, whether it is inside (which is rampant in our schools, workplaces, and homes) or outside. This has followed a major report by WHO: WHO Guide to Indoor Air Quality: Dampness and Mould (July 2009). It is now known that it is false that only immunocompromised people become infected from or ill from mold (fungi). As science learns more, physicians trail behind, pretending that anyone who is afraid of a real threat is crazy. The people who live in these areas need to be alert and concerned. Those whose children attend water-damaged, moldy schools, or those with hidden molds in walls or HVAC systems need to be alert for the evidence that the building is moldy and protect their children's health. go to www.schoolmoldhelp.org for more info. Physicians, stop ridiculing that which you haven't taken the time to understand. Sometimes I think you are the last to know. Why? Because you don't read the research. You keep referring to that which you were trained on - ancient history, in this case. (SMH)

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MSNBC.com


Deadly airborne fungus in Oregon set to spread

The new, rare strain has killed 1 in 4 infected, researchers say

 

By Charles Q. Choi
LiveScience
updated 5:12 p.m. CT, Thurs., April 22, 2010

A deadly, airborne new strain of fungus has emerged in Oregon. It has killed nearly one out of four known affected people so far and might also attack animals ranging from dogs to dolphins. And it is likely to spread, researchers now warn.

The new strain known as VGIIc of the fungus Cryptococcus gattii not only targets humans but has also proven capable of infecting dogs, cats, alpacas, sheep and elk. Other strains have even infected porpoises.

Although it can spread to mammals, it does not jump from animal to animal. Instead, people and other animals get it from inhaling spores released by samples of the fungus that infect trees.

"It's in the environment, and we're exposed to the environment," researcher Edmond Byrnes III of Duke University Medical Center told LiveScience. "And the environmental range of this has been expanding."

Potential to spread
While scientists aren't sure how the highly infectious or virulent fungus emerged in Oregon, they caution the new strain now looks set to expand to California and other neighboring areas.

"This novel fungus is worrisome because it appears to be a threat to otherwise healthy people," Byrnes said. "Typically, we more often see this fungal disease associated with transplant recipients and HIV-infected patients, but that is not what we are seeing yet."

Symptoms can appear two or more months after exposure. Most people never develop symptoms, but those infected may have a cough lasting weeks, sharp chest pain, shortness of breath, headache related to meningitis, fever, nighttime sweats and weight loss. In animals the symptoms are a runny nose, breathing problems, nervous system problems and raised bumps under the skin.

Treatment requires months to years of antifungal medications, and even surgery to remove the large masses of the fungus known as cryptococcomas that can develop in the body. So far it cannot be prevented, as there is no vaccine.

Origin unknown
The fungus C. gattii was originally linked with eucalyptus trees in tropical and subtropical climates. It first caused an outbreak in temperate climes on Vancouver Island in 1999 that has now spread into Washington and Oregon, where it infects local trees. This earlier strain, VGIIa/major, has killed nearly 9 percent of 218 patients.

After comparing the genes of the new VGIIc strain from Oregon with others, researchers suggest the new strain most likely arose recently, parallel to the outbreak that began on Vancouver Island. So far it has killed five out of 21 patients analyzed in the United States, a nearly 25 percent mortality rate. Lab studies with immune cells and with live mice revealed it is extremely virulent — that is, it can cause severe disease.

Determining the exact origin of the VGIIc strain has proven difficult. Investigations so far have failed to find it in Oregon soil, water or trees. It may have arrived from abroad or originated locally, researchers said.

Because this fungus had been confined to the tropics until now, researcher Wenjun Li at Duke University speculated that environmental changes might be responsible for the evolution and emergence of these new strains.

"We are trying to put together the evolutionary story of where these types come from by closely studying the genetics of all samples possible," explained researcher Yonathan Lewit at Duke University Medical Center.

It remains uncertain why VGIIc and VGIIa/major are more virulent than other strains. One possibility, given how this fungus can reproduce sexually, new hypervirulent combinations of genes emerged due to sex. The researchers also noted that cell components known as mitochondria in these strains could adopt a distinctive tube shape. Since mitochondria help generate energy in cells, it is possible these strains are more energetic, "but that's just speculation right now," Byrnes said.

When it comes to a public response to outbreaks of these strains, "public health officials in that area have formed a working group with state epidemiologists from all those states in the Pacific Northwest," Byrnes noted. "It's important that public awareness expand on this."

The scientists detailed their findings online April 22 in the journal PLoS Pathogens.

URL: http://www.msnbc.msn.com/id/36722426/ns/health-infectious_diseases/

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Fatal Fungus Cryptococcus Gattii: Experts Say Fears Overblown

 

Deadly Airborne Fungi Poses Rare Threat

 

By COURTNEY HUTCHISON

ABC News

Apr. 23, 2010—

It sounds like a plot straight out of a science fiction movie: A new strain of a deadly airborne fungus in Oregon is set to spread to California.

But there's no need to sound the alarm, doctors say.

The new strain of the well-known Cryptococcus gattii fungus is "worrisome" because it appears to be a threat to otherwise healthy people, according to a report released today by Duke University Medical Center.

The fungus had previously affected only people with weakened immune systems.

It is absorbed through the lungs and the symptoms of infection, which can appear two to several months after exposure, can include chest pain, shortness of breath, headache, fever and a cough lasting weeks, according to researchers.

Scientists at Duke have called for awareness and vigilance regarding the potentially harmful fungus, but doctors caution that while increased research may be wise, the new strain should not be of concern to the public.

To make a big deal out of this would be "a great example of the manufacturing of risk," said Philip Alcabes, a professor of urban public health at Hunter College School of Health Sciences in New York City.

One would be as likely to be hit by lightning as to be afflicted by this strain, said Dr. William Schaffner, chair of preventive medicine at Vanderbilt University in Nashville, Tenn.

He says the new development is "more of a curiosity" than a threat, one that should only provoke interest in microbiologists and infectious disease specialists.

Despite the caveats, the report, which documents the spread of the deadlier strain and calls for increased vigilance, is poised to trigger public concern.

As with past rare scares, doctors say, the novel and unpredictable nature of the threats can prove difficult to ignore.

Fearing What's Farfetched, Forgetting What's Familiar

Periodically, a virus, or a fungus or a bacterium "will cause a lot of fuss and receive a lot of attention -- unnecessarily," Schaffner said, and then it will disappear from the public eye.

For example, a few years back a rare infectious fungus that you can get from pricking your finger on a rose thorn got some attention.

"It's usually not deadly... but it's hard to diagnose without a specialist so it can go untreated," he said, and then become painful and troublesome.

It can be alarming, he said, "because who hasn't pricked their finger on a rose thorn?"

But that is also the point of his story: Almost everybody has been pricked in their life and almost no one gets the infection, but it's scary to think that something so seemingly harmless -- and random -- could ever wreak havoc in the body.

"It has everything to do with how you perceive the risk," he said.

Other microscopic threats have created buzz in the past, especially after one kind of fungus in a pile of mulch led to the death of a British gardener in 2008.

Another scare occurred in 2002 when one boy died and another was hospitalized after contracting a rare brain infection from an amoeba while swimming in a Florida lake.

The strange and seemingly random hazards are those that are most likely to cause public panic, Schaffner said, even though they also are the least likely to actually afflict anyone.

When the rare threats "take shape in the news, a viewer may perceive a lack of control ...and may thus develop a sense of heightened anxiety or vigilance [about it]," said Kim Liebowitz, director of cardiac behavioral medicine at Bluhm Cardiovascular Institute of Northwestern Memorial Hospital in Chicago.

Vanderbilt's Schaffner said, "If something new pops ups -- if it's novel, mysterious, and if it can strike seemingly anyone, anytime, you suddenly feel like you have no control over the situation. If the threat is disfiguring or life-threatening, if there's no preventative measures you can take against it, these elements invoke fear."

This reaction is known as behavioral conditioning, Liebowitz said, and it means that one can develop strong negative reactions to a threat just by hearing about victims and identifying with them;- no personal experience with the risk required.

Retrain Your Response

At the end of the day, the actual threat the bizarre afflictions pose for any individual is quite small, so it's better to nip needless anxiety in the bud, doctors say.

One way is to see this threat in perspective, said Dr. Robert Betts, infectious disease expert at the University of Rochester in New York.

While 21 cases of C. gattii infection have been documented to date, "hundreds or even thousands have been infected with this fungi, but only a few become ill," he said.

In other words, it's not as though anyone who walks past this spore is doomed to infection.

Also, looking at these rare risks in comparison to the none-too-rare risks we face every day can help highlight one's tendency to be overly anxious about such things, Lebowitz said.

The common fear of flying is a good example of how we misjudge danger.

"So many individuals have a fear of flying despite very safe aviation records," but these same individuals do not fear driving, "which is more dangerous," she said.

It's not the safety records or level of risk people pay attention to, she added, it's the "emotionally laden content" of the stories told about victims of the rare dangers.

As far as the fear of fatal fungi, Alcabes of Hunter College pointed out that the strain is likely to fade out soon.

"In most cases, when new strains arise, they are transient," he says.

Certainly, he said, "it's worth asking, 'Is there some new risk here?'"

But in this particular case, he said, "I see no new threat at all, just a slightly different name for an existing, and rather rare, danger."

As the Director of The Center for School Mold Help, I can say that the same type of naysaying has been used by physicians with regard to the effects of mold (fungi) on health for decades. Even the CDC has now changed its tune - mold (fungi) is dangerous to health, whether it is inside (which is rampant in our schools, workplaces, and homes) or outside. This has followed a major report by WHO: WHO Guide to Indoor Air Quality: Dampness and Mould (July 2009). It is now known that it is false that only immunocompromised people become infected from or ill from mold (fungi). As science learns more, physicians trail behind, pretending that anyone who is afraid of a real threat is crazy. The people who live in these areas need to be alert and concerned. Those whose children attend water-damaged, moldy schools, or those with hidden molds in walls or HVAC systems need to be alert for the evidence that the building is moldy and protect their children's health. go to www.schoolmoldhelp.org for more info. Physicians, stop ridiculing that which you haven't taken the time to understand. Sometimes I think you are the last to know. Why? Because you don't read the research. You keep referring to that which you were trained on - ancient history, in this case.
 
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